Dimension Research

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RMC-6236: A Curious Macrocycle
Macrocycles are a potent, intriguing class of therapies that are growing in importance. Revolution Medicines' RMC-6236 is a perfect example.
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Cryptic Pockets: 'X' Marks the Spot
Cryptic binding pockets are like buried treasure. They're mysterious, difficult to find, and come with untold riches once surfaced.
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Unnatural Amino Acids
The extended amino acid alphabet is full of strangeness, but may hold the key to breakthrough applications in the life sciences.
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Long Live Radiopharmaceuticals!
Radiotherapy is an oncological mainstay. Targeted radiopharmaceuticals are sweeping the clinical landscape, but face substantial hurdles to realize…
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An Opinionated AlphaFold3 Field Guide
I break down every part of AlphaFold3 in simple-to-understand terms and give my observations and opinions along the way.
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Receptors Unite: Agonism with Antibodies
Virtually all FDA-approved antibodies neutralize block cell surface receptors. Why is building an activating (agonizing) antibody interesting? Why has…
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Weekend ADC Musings
Antibody-drug conjugates (ADCs) are here to stay. But how much agreement is there as to how they work, why they're more effective, and why they're more…
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Dimension Research
Dimension Research
Our writings focus on the interface between technology and the life sciences, including areas like—biotech platforms, software infrastructure, lab tools & instrumentation, clinical development, manufacturing & commercialization, as well as AI/ML.

Dimension Research

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