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An Opinionated AlphaFold3 Field Guide
I break down every part of AlphaFold3 in simple-to-understand terms and give my observations and opinions along the way.
Jun 12
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An Opinionated AlphaFold3 Field Guide
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May 2024
Receptors Unite: Agonism with Antibodies
Virtually all FDA-approved antibodies neutralize block cell surface receptors. Why is building an activating (agonizing) antibody interesting? Why has…
May 6
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Receptors Unite: Agonism with Antibodies
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April 2024
Weekend ADC Musings
Antibody-drug conjugates (ADCs) are here to stay. But how much agreement is there as to how they work, why they're more effective, and why they're more…
Apr 21
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Weekend ADC Musings
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February 2024
NeurIPS 2023 Roundup: Drug-Target Interaction (DTI) Prediction
Data on drugs, drug targets, genetic regulatory networks, phenotypes, pathways, and more are proliferating. Pooling everything together to power DTI…
Feb 12
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NeurIPS 2023 Roundup: Drug-Target Interaction (DTI) Prediction
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January 2024
NeurIPS 2023 Roundup: Generative Molecular Design
Similar to therapeutic proteins, NeurIPS 2023 was packed with engaged discussions around the opportunities (and pitfalls!) of generative chemistry…
Jan 25
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NeurIPS 2023 Roundup: Generative Molecular Design
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NeurIPS 2023 Roundup: Generative Protein Design
Generative protein design took center stage at NeurIPS 2023. In part one of a three part series, we highlight several papers, authors, and takeaways…
Jan 21
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NeurIPS 2023 Roundup: Generative Protein Design
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December 2023
Novel Cancer Biomarkers Will Fuel Next-Generation Trial Design
Researchers are gaining a dynamic lens into a tumor's molecular response to therapeutic pressure. As these data are combined with modern ML, how might…
Dec 19, 2023
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Novel Cancer Biomarkers Will Fuel Next-Generation Trial Design
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October 2023
The Isoform Frontier
Our ability to cost-effectively analyze mRNA isoforms at scale will bring profound advancements to basic and translational research. The added…
Oct 23, 2023
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The Isoform Frontier
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September 2023
Old Dogs, New Tricks: Molecular Dynamics can Enhance Protein Degrader Design
Though not discussed as much as machine learning (ML) methods, molecular dynamics are a critical pillar of modern drug design and may hold additional…
Sep 20, 2023
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Old Dogs, New Tricks: Molecular Dynamics can Enhance Protein Degrader Design
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June 2023
Once More Unto the Breach, Dear Friends
Building out a research practice at Dimension.
Jun 13, 2023
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Once More Unto the Breach, Dear Friends
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