Dimension Research

Neuroinflammation: Rethinking Treatment of Brain Disorders

After years of clinical setbacks and deprioritization in neuro drug development, could targeting the brain’s immune system as a new therapeutic…

Sep 4 • 

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June 2025

ASCO 2025: Themes & Takeaways

After attending this year's ASCO conference, we've distilled a list of key concepts spanning checkpoint inhibition, TCR-inspired drugs, tackling…

Jun 18 • 

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Enlicitide: A Curious(er) Macrocycle

Macrocyclic compounds lend themselves to interesting pharmacology. Merck's emerging PCSK9 inhibitor for "bad" cholesterol is no different. Will it…

Jun 13 • 

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May 2025

Don't Fall in Love with Your Molecule

Technical success doesn't guarantee market success. This essay explores how target product profiles align discovery with demand to build enduring…

May 15 • 

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February 2025

CTRL + ALT + DEPLETE

Resetting a dysfunctional immune system via the selective depletion of rogue cells is an emerging therapeutic strategy, having matured in the oncology…

Feb 24 • 

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December 2024

NeurIPS 2024 Open Notes

Our team visited Vancouver to attend NeurIPS 2024. These are our initial notes from many of the AI x Biology workshops.

Dec 22, 2024 • 

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MoML 2024 Open Notes

Our team recently attended the MoML Conference in Boston. We've curated a selection of our notes to push out into the open. Enjoy!

Dec 14, 2024 • 

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October 2024

RMC-6236: A Curious Macrocycle

Macrocycles are a potent, intriguing class of therapies that are growing in importance. Revolution Medicines' RMC-6236 is a perfect example.

Oct 11, 2024 • 

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September 2024

Cryptic Pockets: 'X' Marks the Spot

Cryptic binding pockets are like buried treasure. They're mysterious, difficult to find, and come with untold riches once surfaced.

Sep 13, 2024 • 

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Unnatural Amino Acids

The extended amino acid alphabet is full of strangeness, but may hold the key to breakthrough applications in the life sciences.

Sep 5, 2024 • 

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July 2024

Long Live Radiopharmaceuticals!

Radiotherapy is an oncological mainstay. Targeted radiopharmaceuticals are sweeping the clinical landscape, but face substantial hurdles to realize…

Jul 31, 2024 • 

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June 2024

An Opinionated AlphaFold3 Field Guide

I break down every part of AlphaFold3 in simple-to-understand terms and give my observations and opinions along the way.

Jun 12, 2024 • 

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