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MoML 2024 Open Notes
Our team recently attended the MoML Conference in Boston. We've curated a selection of our notes to push out into the open. Enjoy!
Dec 14
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MoML 2024 Open Notes
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October 2024
RMC-6236: A Curious Macrocycle
Macrocycles are a potent, intriguing class of therapies that are growing in importance. Revolution Medicines' RMC-6236 is a perfect example.
Oct 11
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RMC-6236: A Curious Macrocycle
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September 2024
Cryptic Pockets: 'X' Marks the Spot
Cryptic binding pockets are like buried treasure. They're mysterious, difficult to find, and come with untold riches once surfaced.
Sep 13
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Cryptic Pockets: 'X' Marks the Spot
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Unnatural Amino Acids
The extended amino acid alphabet is full of strangeness, but may hold the key to breakthrough applications in the life sciences.
Sep 5
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Unnatural Amino Acids
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July 2024
Long Live Radiopharmaceuticals!
Radiotherapy is an oncological mainstay. Targeted radiopharmaceuticals are sweeping the clinical landscape, but face substantial hurdles to realize…
Jul 31
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Long Live Radiopharmaceuticals!
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June 2024
An Opinionated AlphaFold3 Field Guide
I break down every part of AlphaFold3 in simple-to-understand terms and give my observations and opinions along the way.
Jun 12
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An Opinionated AlphaFold3 Field Guide
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May 2024
Receptors Unite: Agonism with Antibodies
Virtually all FDA-approved antibodies neutralize block cell surface receptors. Why is building an activating (agonizing) antibody interesting? Why has…
May 6
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Receptors Unite: Agonism with Antibodies
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April 2024
Weekend ADC Musings
Antibody-drug conjugates (ADCs) are here to stay. But how much agreement is there as to how they work, why they're more effective, and why they're more…
Apr 21
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Weekend ADC Musings
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February 2024
NeurIPS 2023 Roundup: Drug-Target Interaction (DTI) Prediction
Data on drugs, drug targets, genetic regulatory networks, phenotypes, pathways, and more are proliferating. Pooling everything together to power DTI…
Feb 12
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NeurIPS 2023 Roundup: Drug-Target Interaction (DTI) Prediction
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January 2024
NeurIPS 2023 Roundup: Generative Molecular Design
Similar to therapeutic proteins, NeurIPS 2023 was packed with engaged discussions around the opportunities (and pitfalls!) of generative chemistry…
Jan 25
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NeurIPS 2023 Roundup: Generative Molecular Design
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NeurIPS 2023 Roundup: Generative Protein Design
Generative protein design took center stage at NeurIPS 2023. In part one of a three part series, we highlight several papers, authors, and takeaways…
Jan 21
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NeurIPS 2023 Roundup: Generative Protein Design
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December 2023
Novel Cancer Biomarkers Will Fuel Next-Generation Trial Design
Researchers are gaining a dynamic lens into a tumor's molecular response to therapeutic pressure. As these data are combined with modern ML, how might…
Dec 19, 2023
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Novel Cancer Biomarkers Will Fuel Next-Generation Trial Design
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