Pretraining: The First Scaling Frontier

Modern AI models are built on the idea that increasing data, model size, and compute drives major performance gains. As these features become harder to…

Dec 11 • Bauer LeSavage and Simon Barnett

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September 2025

Neuroinflammation: Rethinking Treatment of Brain Disorders

After years of clinical setbacks and deprioritization in neuro drug development, could targeting the brain’s immune system as a new therapeutic…

Sep 4 • Bauer LeSavage

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June 2025

ASCO 2025: Themes & Takeaways

After attending this year's ASCO conference, we've distilled a list of key concepts spanning checkpoint inhibition, TCR-inspired drugs, tackling…

Jun 18 • Simon Barnett and Bauer LeSavage

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Enlicitide: A Curious(er) Macrocycle

Macrocyclic compounds lend themselves to interesting pharmacology. Merck's emerging PCSK9 inhibitor for "bad" cholesterol is no different. Will it…

Jun 13 • Simon Barnett

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May 2025

Don't Fall in Love with Your Molecule

Technical success doesn't guarantee market success. This essay explores how target product profiles align discovery with demand to build enduring…

May 15 • Simon Barnett

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February 2025

CTRL + ALT + DEPLETE

Resetting a dysfunctional immune system via the selective depletion of rogue cells is an emerging therapeutic strategy, having matured in the oncology…

Feb 24 • Bauer LeSavage

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December 2024

NeurIPS 2024 Open Notes

Our team visited Vancouver to attend NeurIPS 2024. These are our initial notes from many of the AI x Biology workshops.

Dec 22, 2024 • Simon Barnett and Bauer LeSavage

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MoML 2024 Open Notes

Our team recently attended the MoML Conference in Boston. We've curated a selection of our notes to push out into the open. Enjoy!

Dec 14, 2024 • Simon Barnett

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October 2024

RMC-6236: A Curious Macrocycle

Macrocycles are a potent, intriguing class of therapies that are growing in importance. Revolution Medicines' RMC-6236 is a perfect example.

Oct 11, 2024 • Simon Barnett

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September 2024

Cryptic Pockets: 'X' Marks the Spot

Cryptic binding pockets are like buried treasure. They're mysterious, difficult to find, and come with untold riches once surfaced.

Sep 13, 2024 • Simon Barnett

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Unnatural Amino Acids

The extended amino acid alphabet is full of strangeness, but may hold the key to breakthrough applications in the life sciences.

Sep 5, 2024 • Simon Barnett

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July 2024

Long Live Radiopharmaceuticals!

Radiotherapy is an oncological mainstay. Targeted radiopharmaceuticals are sweeping the clinical landscape, but face substantial hurdles to realize…

Jul 31, 2024 • Simon Barnett

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